AWAYSan Francisco 49ers6-1 · NFC
Scheduled2026 · Week 181/10/27 · 12:00 AM ET
HOMEArizona Cardinals3-5 · NFC
State Farm Stadium Non-conference
Series history Compare teams Defense vs role

Matchup edges

Where each defense ranks top 10 nationally (per game). Roles are inferred from stat lines: QB = 5+ pass attempts, RB = 3+ carries, WR/TE = other receivers.

Full list

San Francisco 49ers defense

MOSTAllows receptions to RB5.6/g3RD MOSTAllows receiving yards to RB38.7/g5TH MOSTAllows completions to QB23.4/g7TH MOSTAllows receptions to WR/TE18.1/g8TH MOSTAllows pass attempts to QB35.0/g

Arizona Cardinals defense

4TH MOSTAllows pass TDs to QB2.4/g4TH MOSTAllows receiving TDs to WR/TE2.1/g6TH MOSTAllows rush attempts to RB24.0/g7TH MOSTAllows rush yards to QB19.6/g9TH MOSTAllows rush yards to RB103.7/g10TH MOSTAllows pass yards to QB243.7/g

Matchup preview

Season per-game numbers with national NFL rank. Bar length = percentile; the better team in each row is highlighted.

San Francisco 49ersArizona Cardinals
Offense
28.1 #4
Points
21.9 #21
371.4 #7
Total Yards
333.0 #17
127.4 #9
Rushing Yards
109.2 #20
244.0 #11
Passing Yards
223.8 #18
50.0% #1
Third Down Percentage
38.7% #5
Defense
19.9 #7
Points Allowed
29.8 #32
299.3 #4
Total Yards Allowed
342.6 #20
89.0 #5
Rushing Yards Allowed
122.1 #19
210.3 #11
Passing Yards Allowed
220.5 #15
37.9% #10
Opponent Third Down Percentage
39.4% #10
Situational
-0.4 #24
Turnover Margin
0.0 #14
2.1 #18
Sacks
2.2 #15
28:51 #27
Time Of Possession
32:24 #4